Inception

Have watched it some time ago but haven't got time to write a review. So now I finish it before I forget. 

First of all, I like the movie. The story is catching, which reminds me of the works of Hitchcock. If we describe a movie as a building, then there is no structural problem. Every part is closely related and presented in an elegant way. 

But there is one thing I feel unsatisfied, probably just my personal taste. Like the dream it discusses, the movie lacks details. Not the plot details I am talking about, but some delicacy I feel missing. I refer to another two my favorite movies, Godfather and Seven Samurai. These are two movies I can appreciate every day. There are always some delicacies that I can amplify and enjoy. However, I do not have the feeling that I should watch Inception for a second time. Still using the building analog, Inception is like a modern skyscraper. Magnificent, fully functional, but not enjoyable. Maybe I shouldn't complain too much, and this is just Nolan style. 

A serious and nice movie, anyway. 

A nice article on virtual screening application to drug design

http://www.nature.com/nrd/journal/v9/n4/full/nrd3139.html

I am not an expert, but most of the points in this article do no require expertise to understand. As far as I know, the author does have a point. For example, the advancement of MD simulation is not just a matter of computation power. It requires a deeper understanding of the behind-the-scene mechanism.

Going a little deeper, I have been thinking the herbal medicines. Why can we find cures from those herbs? Can we find some intrinsic and more traceable connections other than philosophical and ecological explanations? I am not sure if there is an answer to this question, but if there is one, that may be the ultimate solution to drug design problem.